Yohimbine/Yohimbe
OTHERAlso known as: Yohimbe bark, Pausinystalia yohimbe, Yohimbine HCl, Quebrachine
What is Yohimbine/Yohimbe?
Yohimbine is an α2-adrenergic receptor antagonist from yohimbe bark. The pure compound (yohimbine HCl) is an FDA-approved prescription drug for erectile dysfunction. Bark extracts sold as supplements have highly variable yohimbine content (up to 154% variation) with inadequate safety labeling and 5.81x higher serious outcome rate.
Why is Yohimbine/Yohimbe Banned?
Pure yohimbine requires prescription. Bark supplements have dangerous content variability and 5.81x higher odds of serious poisoning outcomes including cardiac events and seizures.
Health Risks & Side Effects
Health Risk Level
This substance has a high risk of overdose and low addiction potential.
warningCommon Side Effects
- arrow_rightCardiac arrhythmias
- arrow_rightHypertension
- arrow_rightMyocardial infarction
- arrow_rightAnxiety
- arrow_rightPanic attacks
- arrow_rightSeizures
blockContraindications
- arrow_rightHeart disease
- arrow_rightAnxiety disorders
- arrow_rightHypertension
- arrow_rightKidney disease
- arrow_rightMAO inhibitor use
- arrow_rightSSRI use
How Does Yohimbine/Yohimbe Work?
Blocks α2-adrenergic receptors, causing increased norepinephrine release throughout the body. Results in elevated blood pressure, heart rate, and anxiety. Also affects fat mobilization.
History
Traditional use in West Africa as aphrodisiac. Yohimbine HCl approved as prescription drug for ED. Bark supplements are poorly regulated with a 2015 analysis of 49 supplements showing highly variable and often undisclosed yohimbine content.
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Learn More
Research articles and educational resources
Overview
Corynanthe johimbe
Corynanthe johimbe, synonym Pausinystalia johimbe, common name yohimbe, is a plant species in the family Rubiaceae native to western and central Africa.
Scientific Research
From PubMed • 1 peer-reviewed study
Sexual Performance Anxiety.
Sexual performance anxiety (SPA) is one of the most prevalent sexual complaints; yet, no diagnosis is recognized for either gender. Thus, research into treatment has been minimal.